Lithium Hydroxide → HCID 10304359、化合物

HRID 396064ノート

反応式

HRID 396064 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[CH2:14][NH:15][C:16]([N:18]1[CH2:23][CH2:22][CH:21]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][NH:33][CH2:34][C@H:35]([OH:45])[CH2:36][O:37][C:38]3[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][CH:39]=3)=[CH:27][CH:26]=2)[CH2:20][CH2:19]1)=[O:17])[O:5][CH2:6][C:7]([O:9]C)=[O:8].[Li+].[OH-]>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[CH2:14][NH:15][C:16]([N:18]1[CH2:19][CH2:20][CH:21]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][NH:33][CH2:34][C@H:35]([OH:45])[CH2:36][O:37][C:38]3[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][CH:39]=3)=[CH:27][CH:26]=2)[CH2:22][CH2:23]1)=[O:17])[O:5][CH2:6][C:7]([OH:9])=[O:8]

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 69987239HCID 69987239、化合物

生成物 1

HCID 10304359HCID 10304359、化合物収率 50%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 2-(3-fluoro-4-{[({4-[4-(2-{[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino)ethyl)anilino]-1-piperidinyl}carbonyl)amino]methyl}phenoxy)acetate (0.107 g, 0.2 mmol) was dissolved in tetrahydrofuran. To this solution was added 1N LiOH (2 mL, 0.2 mmol) and stirred at ambient temperature for four days. The solvent was removed in vacuo and the resulting solid lyophilized to yield the title compound (0.075 g, 0.1 mmol).

後処理

  1. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-03c90b59070d4c33aa8b74a409bc421d
出典データセット
uspto-grants-2003_08
特許番号
US06605618B2

反応ノート

読み込み中…