Cl.[K].NC1C=CC(F)=CC=1S.O.[C:13]1([CH3:23])[CH:18]=[CH:17][C:16]([S:19]([OH:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1>O1CCCC1.O>[CH3:23][C:13]1[CH:18]=[CH:17][C:16]([S:19]([OH:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1
80 ml of water and 60 g (0.592 mole) of 36% hydrochloric acid were placed in a 500-ml flask as a reactor, and cooled to 2° C. Thereto was dropwise added, at 0 to 5° C. with stirring, 96.1 g (0.112 mole) of an aqueous solution of a potassium salt of 2-amino-5-fluorothiophenol, followed by stirring for 1 hour. The system had a pH of 5.02. Thereto were added 19.4 g (0.102 mole) of p-toluenesulfonic acid monohydrate and 25 ml of tetrahydrofuran, followed by stirring for 30 minutes. Thereto was added 16.2 g (0.110 mole) of D-alanine-N-carboxyanhydride (purity: 78.3%) at 0° C. The resulting mixture was aged at 15 to 20° C. for 18 hours. The resulting crystals were collected by filtration and dried at 60° C. to obtain 30.9 g of a p-toluenesulfonate of [2-(6-fluorobenzothiazolyl)]ethylamine (purity: 92%) (the yield was 75.6% relative to the potassium salt of 2-amino-5-fluorothiophenol).
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