Methyl phenylacetate → Benzeneacetic acid, alpha-bromo-, methyl ester
反応式
[Br:1]N1C(=O)CCC1=O.[C:9]1([CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:1][CH:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:16]([O:18][CH3:19])=[O:17]参加物
5
反応条件
- 温度
- 0 °C
実験手順
In this example, a mixture containing 5.93 g of N-bromosuccinimide, 5.0 g of methyl phenylacetate; and a catalytic amount (about 0.1 g) of benzoyl peroxide in 50 ml of carbon tetrachloride was warmed to reflux and then refluxed for about 12 hours. The mixture was then cooled to about 0° C. and filtered. The filtrate was concentrated by evaporation under vacuum affording 7.1 g of the title compound as an oil.
後処理
- temperatureto reflux
- temperaturerefluxed for about 12 hours
- filtrationfiltered
- concentrationThe filtrate was concentrated by evaporation under vacuum
出典と根拠
- ORDレコード
- ord-5dcd18cf32f744b38e1a3a9e2e554156
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04723031
反応ノート
読み込み中…