Methyl phenylacetate → Benzeneacetic acid, alpha-bromo-, methyl ester

HRID 3973

反応式

HRID 3973 の反応式
[Br:1]N1C(=O)CCC1=O.[C:9]1([CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:1][CH:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:16]([O:18][CH3:19])=[O:17]

参加物

5

反応物 2

HCID 7559Methyl phenylacetateHCID 67184N-bromobutanimide

生成物 1

HCID 137806Benzeneacetic acid, alpha-bromo-, methyl ester収率 93.1%

試薬・触媒・溶媒 2

HCID 7187Benzoyl Peroxide触媒HCID 5943Carbon Tetrachloride溶媒

反応条件

温度
0 °C

実験手順

In this example, a mixture containing 5.93 g of N-bromosuccinimide, 5.0 g of methyl phenylacetate; and a catalytic amount (about 0.1 g) of benzoyl peroxide in 50 ml of carbon tetrachloride was warmed to reflux and then refluxed for about 12 hours. The mixture was then cooled to about 0° C. and filtered. The filtrate was concentrated by evaporation under vacuum affording 7.1 g of the title compound as an oil.

後処理

  1. temperatureto reflux
  2. temperaturerefluxed for about 12 hours
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated by evaporation under vacuum

出典と根拠

ORDレコード
ord-5dcd18cf32f744b38e1a3a9e2e554156
出典データセット
uspto-grants-1988_02
特許番号
US04723031

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