N-Iodosuccinimide → 6-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene

HRID 397320ノート

反応式

HRID 397320 の反応式
[I:1]N1C(=O)CCC1=O.[CH:9]1([O:12][C:13]2[CH:21]=[CH:20][C:19]3[N:18]4[CH2:22][CH2:23][CH2:24][C:17]4=[CH:16][C:15]=3[CH:14]=2)[CH2:11][CH2:10]1>C(#N)C>[CH:9]1([O:12][C:13]2[CH:21]=[CH:20][C:19]3[N:18]4[CH2:22][CH2:23][CH2:24][C:17]4=[C:16]([I:1])[C:15]=3[CH:14]=2)[CH2:11][CH2:10]1

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 230001076-Cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene

生成物 1

HCID 230001116-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene収率 72.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

18.5 g N-iodosuccinimide at 0° C. was added to a solution of 17.55 g 6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene in acetonitrile and the mixture was stirred at this temperature for 15 min. The solid was collected by filtration, washed with cold acetonitrile and dried to constant weight to yield 20.1 g 6-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene as beige crystals melting at 104-105° C.

後処理

  1. filtrationThe solid was collected by filtration
  2. washwashed with cold acetonitrile
  3. customdried to constant weight

出典と根拠

ORDレコード
ord-0c9f49d70225419a963bb6fba251828d
出典データセット
uspto-grants-2003_08
特許番号
US06610685B2

反応ノート

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