ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

4-Methylmorpholine → N'2-acetyl-(2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarbohydrazide

HRID 397664
ノート
印刷プレビュー

反応式

HRID 397664 の反応式
O.ON1C2C=CC=CC=2N=N1.[C:12]([NH:15][NH2:16])(=[O:14])[CH3:13].CN1CCOCC1.CN(C)CCCN=C=NCC.[F:35][C:36]1[CH:41]=[CH:40][C:39]([S:42]([N:45]2[CH2:50][CH2:49][CH2:48][CH2:47][C@H:46]2[C:51](O)=[O:52])(=[O:44])=[O:43])=[CH:38][CH:37]=1>ClCCl>[C:12]([NH:15][NH:16][C:51]([C@@H:46]1[CH2:47][CH2:48][CH2:49][CH2:50][N:45]1[S:42]([C:39]1[CH:38]=[CH:37][C:36]([F:35])=[CH:41][CH:40]=1)(=[O:44])=[O:43])=[O:52])(=[O:14])[CH3:13]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 5

HCID 79724-MethylmorpholineHCID 14039AcetohydrazideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 768662(2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarboxylic acidHCID 27960291-Hydroxybenzotriazole hydrate

生成物 1

HCID 57053283N'2-acetyl-(2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarbohydrazide
収率 99.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1-Hydroxybenzotriazole hydrate (162 mg), acethydrazide (81 mg), N-methylmorpholine (275 μl) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (230 mg) were added to a stirred solution of (2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarboxylic acid [see Preparation 38] (287 mg) in dichloromethane (3 ml). The reaction mixture was stirred for 3 hours after which time the mixture was partitioned between dichloromethane and water. The organic layer was separated, dried over magnesium sulphate and the solvent removed under reduced pressure to afford N′2-acetyl-(2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarbohydrazide (340 mg) as a white solid.

後処理

  1. customwas partitioned between dichloromethane and water
  2. customThe organic layer was separated
  3. dry with materialdried over magnesium sulphate
  4. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-fccb8fef80894d168aa330d44a040911
出典データセット
uspto-grants-2003_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06610707B1

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート