Hydrochloric Acid → 3-(Oxan-2-yl)propanoic acid
反応式
[OH-].[Li+].[O:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][CH2:10][C:11]([O:13]C)=[O:12].Cl>O1CCCC1>[O:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][CH2:10][C:11]([OH:13])=[O:12]参加物
5
実験手順
A 2M aqueous solution of lithium hydroxide (4 ml) was added to a solution of methyl 3-(tetrahydropyran-2-yl)propanoate (Preparation 25, 460 mg, 2.67 mmol) in tetrahydrofuran (16 ml) and the reaction mixture was heated under reflux for 10 h. The cooled reaction mixture was acidified with 2N aqueous hydrochloric acid to pH 1 and extracted with ethyl acetate (3×50 ml). The combined extracts were washed with brine (30 ml), dried (MgSO4), filtered and concentrated in vacuo to give the title compound as a colourless oil (460 mg, 67%).
後処理
- temperaturethe reaction mixture was heated
- temperatureunder reflux for 10 h
- customThe cooled reaction mixture
- extractionextracted with ethyl acetate (3×50 ml)
- washThe combined extracts were washed with brine (30 ml)
- dry with materialdried (MgSO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-3769e7c605bd41f9975ef254e9452731
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610711B2
反応ノート
読み込み中…