Acetic Acid → HCID 23445018、化合物

HRID 397930

反応式

HRID 397930 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1)[NH2:5].[CH:13](OCC)(OCC)OCC.[N+:23]([CH2:26]C(OCC)=O)([O-])=O.[C:32]([OH:35])(=[O:34])[CH3:33]>[Fe]>[F:1][C:2]1[CH:3]=[C:4]([N:5]2[CH:13]=[C:33]([C:32]([OH:35])=[O:34])[N:23]=[CH:26]2)[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

参加物

6

反応物 4

HCID 176Acetic Acid2 回HCID 31214Ethyl orthoformate2 回HCID 69379Ethyl nitroacetateHCID 27359133-Amino-5-fluorobenzotrifluoride

生成物 1

HCID 23445018HCID 23445018、化合物

試薬・触媒・溶媒 1

HCID 23925Iron触媒

実験手順

Following the general method described in example 234, 3-fluoro-5-trifluoromethylaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a white crystalline solid. Mp.>250° C. (H2O/dioxane), MS: m/e=273 (M−H−).

出典と根拠

ORDレコード
ord-b147aa1cff6e43aeaab32b572cddd72d
出典データセット
uspto-grants-2003_08
特許番号
US06610723B2

関連ノート

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