Diethyl Carbonate → 4-Ethyl-4-hydroxymethyl-2-oxazolidinone

HRID 398813

反応式

HRID 398813 の反応式
[NH2:1][C:2]([CH2:7][CH3:8])([CH2:5][OH:6])[CH2:3][OH:4].[C:9](=O)(OCC)[O:10]CC>C[O-].[Na+].CCO>[CH2:7]([C:2]1([CH2:5][OH:6])[CH2:3][O:4][C:9](=[O:10])[NH:1]1)[CH3:8]

参加物

5

反応物 2

HCID 7766Diethyl CarbonateHCID 82822-Amino-2-ethyl-1,3-propanediol

生成物 1

HCID 112635594-Ethyl-4-hydroxymethyl-2-oxazolidinone収率 66.5%

試薬・触媒・溶媒 2

HCID 10942334Sodium Methoxide触媒HCID 702Ethanol溶媒

実験手順

Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol(100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone(200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.

後処理

  1. customwas collected
  2. temperatureThe reaction mixture was cooled
  3. additionadded acetone(200 ml)
  4. customto stand overnite at room temperature
  5. filtrationThe resulting suspension was filtered

出典と根拠

ORDレコード
ord-58e4b581318740f5b42cfeb857ddca99
出典データセット
uspto-grants-1998_10
特許番号
US05817652

関連ノート

読み込み中…