Diethyl Carbonate → 4-Ethyl-4-hydroxymethyl-2-oxazolidinone
反応式
[NH2:1][C:2]([CH2:7][CH3:8])([CH2:5][OH:6])[CH2:3][OH:4].[C:9](=O)(OCC)[O:10]CC>C[O-].[Na+].CCO>[CH2:7]([C:2]1([CH2:5][OH:6])[CH2:3][O:4][C:9](=[O:10])[NH:1]1)[CH3:8]参加物
5
実験手順
Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol(100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone(200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.
後処理
- customwas collected
- temperatureThe reaction mixture was cooled
- additionadded acetone(200 ml)
- customto stand overnite at room temperature
- filtrationThe resulting suspension was filtered
出典と根拠
- ORDレコード
- ord-58e4b581318740f5b42cfeb857ddca99
- 出典データセット
- uspto-grants-1998_10
- 特許番号
- US05817652
反応ノート
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