Pyridine → 21H,22H-Porphine

HRID 400314

反応式

HRID 400314 の反応式
C(C1C=CC([C:10]2[C:29]3[NH:30][C:26](=[CH:27][CH:28]=3)[C:25](C3C=CC(C(O)=O)=CC=3)=[C:24]3[N:40]=[C:21]([CH:22]=[CH:23]3)[C:20](C3C=CC(C(O)=O)=CC=3)=[C:19]3[NH:50][C:16]([CH:17]=[CH:18]3)=[C:15](C3C=CC(C(O)=O)=CC=3)[C:14]3=[N:60][C:11]=2[CH:12]=[CH:13]3)=CC=1)(O)=O.N1C=CC=CC=1.ClC(OCC(C)C)=O>CS(C)=O>[C:26]12[CH:25]=[C:24]3[N:40]=[C:21]([CH:22]=[CH:23]3)[CH:20]=[C:19]3[NH:50][C:16]([CH:17]=[CH:18]3)=[CH:15][C:14]3=[N:60][C:11]([CH:12]=[CH:13]3)=[CH:10][C:29]([NH:30]1)=[CH:28][CH:27]=2

参加物

5

反応物 3

HCID 1049PyridineHCID 62365Isobutyl chloroformateHCID 86278368meso-Tetra(4-carboxyphenyl)porphine

生成物 1

HCID 13770524121H,22H-Porphine

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

The synthesis was performed in a three-necked flask under nitrogen. 50 mg of mezo-tetra(4-carboxyphenyl)porphine (4CP) was dissolved in 5 ml of dry DMSO, the catalysts, i.e. 120 μl of pyridine and 30 μl of isobutyl chloroformate, were added and after 5 minutes a suspension of 0.5 g Cloisite 30 B in 15 ml of dry DMSO was added. The reaction mixture was mixed at 70° C. for 4 hours. The product obtained was filtered on a Buchner funnel with a sintered glass disc and washed with methanol till the transparent filtrate was obtained and then the product was dried in a vacuum dryer. A green powder was obtained.

後処理

  1. customThe synthesis was performed in a three-necked flask under nitrogen
  2. additionwas added
  3. additionThe reaction mixture was mixed at 70° C. for 4 hours
  4. customThe product obtained
  5. filtrationwas filtered on a Buchner funnel with a sintered glass disc
  6. washwashed with methanol till the transparent filtrate
  7. customwas obtained
  8. customthe product was dried in a vacuum dryer
  9. customA green powder was obtained

出典と根拠

ORDレコード
ord-2bfb35ad99f94463b0bf921b96521cff
出典データセット
uspto-grants-2014_06
特許番号
US08741156B2

関連ノート

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