Tetrahydrofuran → 2-Vinyl-6-methoxynaphthalene

HRID 400339

反応式

HRID 400339 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](C=O)=[CH:8][CH:7]=[CH:6]2.[CH2:15]1COC[CH2:16]1>CCOCC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:15]=[CH2:16])[CH:7]=[CH:6]2

参加物

4

反応物 2

HCID 8028TetrahydrofuranHCID 128430406-Methoxynaphthalene-1-carbaldehyde

生成物 1

HCID 6035352-Vinyl-6-methoxynaphthalene収率 90%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

6-Methoxy-naphthaldehyde (432 mg, 2.35 mmol) is added to a solution of instantaneous ylide (Ph3P+Br−+NaNH2, 1.48 g, 2.4 mmol) in anhydrous THF (5 ml). After one hour of stirring at ambient temperature, it is diluted with ether, it is filtered on Celite, and it is chromatographed (hexane/AcOEt 5:1) to obtain 6-methoxy-2-vinyl-naphthalene (390 mg, 90%).

後処理

  1. filtrationis filtered on Celite, and it
  2. customis chromatographed (hexane/AcOEt 5:1)

出典と根拠

ORDレコード
ord-26a379baa01243c797c0116c08dda5b4
出典データセット
uspto-grants-2014_06
特許番号
US08741593B2

関連ノート

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