Sodium Azide → 1-(Azidomethyl)-4-methoxybenzene
反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][CH:4]=1.[N-:11]=[N+:12]=[N-:13].[Na+]>C(#N)C>[N:11]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][CH:4]=1)=[N+:12]=[N-:13]参加物
4
実験手順
A mixture of 1-(chloromethyl)-4-methoxybenzene (20 g, 128 mmol) and sodium azide (12.5 g, 192 mmol) in acetonitrile (255 mL) was refluxed for 5 h under N2 atmosphere. The mixture was filtered and concentrated in vacuo. The residue was diluted with DCM, washed with H2O and brine, dried over Na2SO4 and concentrated in vacuo to afford crude 1-(azidomethyl)-4-methoxybenzene. The residue was used for the next reaction without further purification.
後処理
- temperaturewas refluxed for 5 h under N2 atmosphere
- filtrationThe mixture was filtered
- concentrationconcentrated in vacuo
- additionThe residue was diluted with DCM
- washwashed with H2O and brine
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-fc28325b20f2478a9afe2ef9177b7065
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08741906B2
反応ノート
読み込み中…