Thionyl Chloride → 4-([[3-Chloro-4-(trifluoromethyl)benzyl]amino]carbonyl)benzenesulfonyl chloride

HRID 401773

反応式

HRID 401773 の反応式
[K+].[S:2]([C:6]1[CH:14]=[CH:13][C:9]([C:10]([O-:12])=O)=[CH:8][CH:7]=1)([OH:5])(=[O:4])=O.[Cl:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[C:24]([F:27])([F:26])[F:25])[CH2:19][NH2:20].S(Cl)([Cl:30])=O>>[Cl:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[C:24]([F:25])([F:26])[F:27])[CH2:19][NH:20][C:10]([C:9]1[CH:8]=[CH:7][C:6]([S:2]([Cl:30])(=[O:4])=[O:5])=[CH:14][CH:13]=1)=[O:12]

参加物

4

反応物 3

HCID 24386Thionyl ChlorideHCID 235127443-Chloro-4-(trifluoromethyl)benzylamineHCID 23670833Potassium 4-carboxybenzenesulfonate

生成物 1

HCID 577319284-([[3-Chloro-4-(trifluoromethyl)benzyl]amino]carbonyl)benzenesulfonyl chloride収率 45%

実験手順

The title compound was prepared from 4-sulphobenzoic acid monopotassium salt and 3-chloro-4-(trifluoromethyl)benzylamine in 45% yield following the procedure described in Preparation 1. The thionyl chloride solution was heated at reflux for 3 hours.

後処理

  1. customdescribed in Preparation 1
  2. temperatureat reflux for 3 hours

出典と根拠

ORDレコード
ord-744406d3034340fcb6671c74fe7e611b
出典データセット
uspto-grants-2014_06
特許番号
US08741934B2

関連ノート

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