Ammonia → 5-Methoxypyridin-3-ylamine

HRID 40256

反応式

HRID 40256 の反応式
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.[OH-].[Na+].[NH3:12]>[O-]S([O-])(=O)=O.[Cu+2]>[NH2:12][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 14798Sodium HydroxideHCID 8171633-Bromo-5-methoxypyridine

生成物 1

HCID 127035955-Methoxypyridin-3-ylamine

試薬・触媒・溶媒 1

HCID 24462Copper Sulfate触媒

反応条件

温度
135 °C

実験手順

3-Bromo-5-methoxypyridine (15 g) was added to a pressure vessel, and CuSO4 (3.9 g) and 25% aq ammonia (150 mL) were added. The reaction mixture was stirred for 4 h at 135° C., then cooled to RT, basified with aqueous NaOH solution, and extracted with CH2Cl2. After evaporation of volatiles, 3-amino-5-methoxypyridine was obtained as yellow solid.

後処理

  1. temperaturecooled to RT
  2. extractionextracted with CH2Cl2
  3. customAfter evaporation of volatiles

出典と根拠

ORDレコード
ord-2201f9415fc24aaa9edc6fe64207147c
出典データセット
uspto-grants-2013_09
特許番号
US08524900B2

関連ノート

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