Azobisisobutyronitrile → 1,3-Dibromo-5-(bromomethyl)-2-chlorobenzene

HRID 402825ノート

反応式

HRID 402825 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([Br:9])[C:3]=1[Cl:10].C1C(=O)N([Br:18])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>>[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][Br:18])[CH:5]=[C:4]([Br:9])[C:3]=1[Cl:10]

参加物

4

反応物 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 229702894-Chloro-3,5-dibromotoluene

生成物 1

HCID 667653881,3-Dibromo-5-(bromomethyl)-2-chlorobenzene収率 57.9%

実験手順

To 1,3-dibromo-2-chloro-5-methylbenzene (1000 mg, 3.52 mmol) was added NBS (688 mg, 3.87 mmol) and AIBN (57.7 mg, 0.352 mmol). The mixture was stirred at room temperature for 30 minutes and then heated to 80° C. overnight. The solution was evaporated and the residue was purified by silica gel chromatography (0-5% EtOAc/heaxnes) to provide the title compound (740 mg) as a clear oil.

後処理

  1. temperatureheated to 80° C. overnight
  2. customThe solution was evaporated
  3. customthe residue was purified by silica gel chromatography (0-5% EtOAc/heaxnes)

出典と根拠

ORDレコード
ord-fdbe0c5583ad4acf86d51d17badb808e
出典データセット
uspto-grants-2014_06
特許番号
US08742110B2

反応ノート

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