Piperidine → Methyl 2-(3-fluorophenyl)-2-(piperidin-1-yl)acetate
反応式
Br[CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.CCN(C(C)C)C(C)C>C(#N)C>[F:13][C:9]1[CH:8]=[C:7]([CH:2]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:3]([O:5][CH3:6])=[O:4])[CH:12]=[CH:11][CH:10]=1参加物
5
実験手順
Methyl 2-bromo-2-(3-fluorophenyl)acetate (310 mg, 1.25 mmol), piperidine (0.15 ml, 1.51 mmol), and DIPEA (0.26 ml, 1.51 mmol) were dissolved in acetonitrile (15 ml) and stirred at room temperature for 16 hours. The solvent was evaporated and the crude was purified by flash chromatography (petroleum ether/EtOAc=9/1) to afford methyl 2-(3-fluorophenyl)-2-(piperidin-1-yl)acetate (224 mg, 71% yield) as a colorless oil.
後処理
- customThe solvent was evaporated
- customthe crude was purified by flash chromatography (petroleum ether/EtOAc=9/1)
出典と根拠
- ORDレコード
- ord-2002643b8173492fa440e1c574b11f04
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748613B2
反応ノート
読み込み中…