Hydrochloric Acid → 2-Acetamido-4-phenyl-1,3-thiazole-5-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[S:10][C:9]([NH:11][C:12](=[O:14])[CH3:13])=[N:8][C:7]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:5])C.[OH-].[Na+].[Li+].[OH-].Cl>O>[C:12]([NH:11][C:9]1[S:10][C:6]([C:4]([OH:5])=[O:3])=[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:8]=1)(=[O:14])[CH3:13]参加物
6
実験手順
To 2.2 g (7.62 mmol) 2-acetylamino-4-phenyl-thiazole-5-carboxylic acid ethyl ester in 10 mL water is added 5 mL 4N NaOH and the mixture is allowed to stand at rt for 12 h. 1 g LiOH is added and the mixture is allowed to stand at rt for 2 h. The mixture is neutralized with aq. 2 N HCl solution and the precipitate is collected and washed with water and ACN to yield the desired product.
後処理
- waitto stand at rt for 2 h
- customthe precipitate is collected
- washwashed with water and ACN
出典と根拠
- ORDレコード
- ord-496a958ae2bf4b89a73f788ab13f82d9
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530461B2
反応ノート
読み込み中…