1,2-Dichloroethane → 2-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide

HRID 405220

反応式

HRID 405220 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Br:15][C:16]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:17]=1[C:18](O)=[O:19].C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.C(N(C(C)C)CC)(C)C>C1COCC1>[Br:15][C:16]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:17]=1[C:18]([NH:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)=[CH:9][CH:10]=1)=[O:19]

参加物

7

反応物 5

HCID 111,2-DichloroethaneHCID 86754-Amino-4'-chlorodiphenylHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 2262922-Bromo-4-methylbenzoic acid

生成物 1

HCID 710600832-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4′-chloro-[1,1′-biphenyl]-4-amine (159 mg, 0.78 mmol), 2-bromo-4-methylbenzoic acid (140 mg, 0.65 mmol), EDC (125 mg, 0.65 mmol), HOBt (100 mg, 0.65 mmol), and diisopropylethyl amine (0.22 mL, 1.30 mmol) were dissolved in THF (2.6 mL) and stirred at room temperature. After 3 h the resulting mixture directly purified via column chromatography to yield the title compound.

後処理

  1. customAfter 3 h the resulting mixture directly purified via column chromatography

出典と根拠

ORDレコード
ord-5c7d59f64ce94b76a6e62c06cf8ab6b8
出典データセット
uspto-grants-2014_06
特許番号
US08748624B2

関連ノート

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