反応式
[Li+].CC([N-]C(C)C)C.[Cl:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([O:20][CH2:21][O:22][CH3:23])[CH:11]=1.CN([CH:27]=[O:28])C>C1COCC1>[Cl:9][C:10]1[CH:15]=[C:14]([C:16]([F:18])([F:19])[F:17])[CH:13]=[C:12]([O:20][CH2:21][O:22][CH3:23])[C:11]=1[CH:27]=[O:28]参加物
5
反応条件
- 温度
- 0 °C
実験手順
A 1.6M LDA solution (12.6 mL, 20.1 mmol) was added to a −78° C. THF solution (50 mL) of 1-chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene (from above). After 30 min neat DMF (3.9 mL, 50.0 mmol) was added, and the resulting solution was allowed to warm to 0° C. gradually, quenched with NH4Cl solution, and extracted with diethyl ether. The combined extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.
後処理
- customquenched with NH4Cl solution
- extractionextracted with diethyl ether
- dry with materialThe combined extracts were dried (Na2SO4)
- concentrationconcentrated
- custompurified via column chromatography
出典と根拠
- ORDレコード
- ord-18cdfcacb0de4a1bac2fe48d611cf668
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748624B2
関連ノート
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