Potassium Phosphate, Tribasic → 2-Chloro-5-cyclopropylpyrimidine

HRID 40564

反応式

HRID 40564 の反応式
Br[C:2]1[CH:3]=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH:9]1(B(O)O)[CH2:11][CH2:10]1.[O-]P([O-])([O-])=O.[K+].[K+].[K+].C1(P(C2CCCCC2)C2CCCCC2)CCCCC1>CC([O-])=O.CC([O-])=O.[Pd+2].C1(C)C=CC=CC=1.O>[Cl:8][C:5]1[N:4]=[CH:3][C:2]([CH:9]2[CH2:11][CH2:10]2)=[CH:7][N:6]=1

参加物

8

反応物 4

HCID 62657Potassium Phosphate, TribasicHCID 75806TricyclohexylphosphineHCID 6066655-Bromo-2-chloropyrimidineHCID 2760897Cyclopropylboronic acid

生成物 1

HCID 468640872-Chloro-5-cyclopropylpyrimidine

試薬・触媒・溶媒 3

HCID 167845palladium(II) acetate触媒HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

3.60 g (18.6 mmol) 5-bromo-2-chloropyrimidine, 4.80 g (55.8 mmol) cyclopropyl boronic acid, 13.8 g (65.1 mmol) K3PO4,568 mg (2.03 mmol) tricyclohexylphosphine and 4 mL water are added to 80 mL toluene. The mixture is degassed thoroughly and charged with 627 mg (2.79 mmol) Pd(OAc)2. After degassing again the mixture is stirred at 100° C. over night, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc 90/10→70/30).

後処理

  1. customThe mixture is degassed thoroughly
  2. customAfter degassing again the mixture
  3. filtrationfiltered
  4. customthe solvent is removed in vacuo
  5. customThe crude product is purified by column chromatography (silica gel, PE/EtOAc 90/10→70/30)

出典と根拠

ORDレコード
ord-61973ad4c4ec4f6fa03b98ec4f2b656c
出典データセット
uspto-grants-2013_09
特許番号
US08530460B2

関連ノート

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