Methanol → NaMAU AMPS

HRID 405652

反応式

HRID 405652 の反応式
CO.[C:3]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O-:21])=[O:20])(=[O:7])[C:4]([CH3:6])=[CH2:5].[Na+:22].[C:23]([NH:27][C:28]([CH3:35])([CH3:34])[CH2:29][S:30]([OH:33])(=[O:32])=[O:31])(=[O:26])[CH:24]=[CH2:25].[OH-].[Na+]>N(C(C)(C)C#N)=NC(C)(C)C#N.CCOCC.O>[C:3]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O-:21])=[O:20])(=[O:7])[C:4]([CH3:6])=[CH2:5].[Na+:22].[C:23]([NH:27][C:28]([CH3:35])([CH3:34])[CH2:29][S:30]([OH:33])(=[O:31])=[O:32])(=[O:26])[CH:24]=[CH2:25]

参加物

8

反応物 4

HCID 887MethanolHCID 14798Sodium HydroxideHCID 653602-Acrylamido-2-methyl-1-propanesulfonic acidHCID 87229187Sodium 11-methacrylamidoundecanoate

生成物 1

HCID 131731611NaMAU AMPS収率 619.5%

試薬・触媒・溶媒 3

HCID 6547Azobisisobutyronitrile触媒HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

反応条件

温度
60 °C

実験手順

Into a mixed solvent of 32.4 mL of methanol and 3.6 mL water (methanol/water=9/1) were dissolved 4.9823 g (17.1 mmol) of sodium 11-methacrylamidoundecanoate (NaMAU), 186.5 mg (0.9 mmol) of 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 39.6 mg (0.99 mmol) of sodium hydroxide, and 7.4 mg (0.045 mmol) of azobisisobutyronitrile. The solution was deaerated by bubbling argon for 30 minutes, the container was covered with a septum, and the polymerization was conducted by heating the solution at 60° C. for 12 hours. After the completion of the polymerization reaction, the reaction solution was dropwise added into a large excess of ether, and the resulting precipitate was collected by filtration under suction. This precipitate was dissolved in water, dialyzed against pure water for 1 week, and 2.78 g of random NaMAU/AMPS copolymer (95/5) was obtained by freeze-drying (yield: 53.71%).

後処理

  1. customby bubbling argon for 30 minutes
  2. customAfter the completion of the polymerization reaction
  3. filtrationthe resulting precipitate was collected by filtration under suction
  4. dissolutionThis precipitate was dissolved in water
  5. customdialyzed against pure water for 1 week

出典と根拠

ORDレコード
ord-e74563a5dfd343de944fdb3e46ef7ccc
出典データセット
uspto-grants-2014_06
特許番号
US08753686B2

関連ノート

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