Ammonia → 3-(4-Chlorophenyl)-6-iodopyridazine
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[Na+].[I-:16].Cl.N>O.C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[N:10][C:11]([I:16])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1参加物
7
反応条件
- 温度
- 80 °C
実験手順
20 mL ACN are added to 0.50 g (1.11 mmol) 3-(4-chlorophenyl)-6-chloropyridazine and 3.33 g (22.2 mmol) NaI before 189 μl fuming conc. HCl are added and the mixture is stirred at 80° C. for 4 h. The mixture is alkalised with aq. ammonia solution (32%) diluted with water and extracted with EtOAc. The org. phases are combined, dried with Na2SO4 and the solvent is removed in vacuo. The resulting crude product is triturated with TBME.
後処理
- additionare added
- extractionextracted with EtOAc
- dry with materialdried with Na2SO4
- customthe solvent is removed in vacuo
- customThe resulting crude product is triturated with TBME
出典と根拠
- ORDレコード
- ord-76001af253f34f63a8e9af4acd8ded6a
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530460B2
反応ノート
読み込み中…