Water → rac-(1R,2R)-2-(methylamino)cyclohexan-1-ol
反応式
C(O[C:6](=O)[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[OH:14])(C)(C)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>C1COCC1>[CH3:6][NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[OH:14]参加物
6
実験手順
3.51 g racemic trans-(2-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester were added to a suspension of 3.09 g lithium aluminium hydride in THF. The reaction mixture was heated at reflux over night. After that time subsequently 3.1 ml water, 3.1 ml sodium hydroxide solution (2M) and 3.1 ml water were added. The mixture was then stirred for 45 minutes and then filtered through celite. The celite was washed with EtOAc. The solvent was evaporated.
後処理
- temperatureThe reaction mixture was heated
- temperatureat reflux over night
- filtrationfiltered through celite
- washThe celite was washed with EtOAc
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-9f9e80c4270e41e28f4c7d270229b3a1
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08754079B2
反応ノート
読み込み中…