Water → (5-Bromo-2-chlorophenyl)methanol

A solution of methyl 5-bromo-2-chlorobenzoate (9.23 g) in THF (50 ml) was added dropwise under ice-cooling to a suspension of lithium aluminum hydride (1.42 g) in THF (100 ml). After the completion of addition, the reaction mixture was stirred at room temperature for 45 minutes. Water (1.4 ml), 5N sodium hydroxide solution (1.4 ml) and water (4.2 ml) were sequentially added under ice-cooling to the reaction mixture. The precipitate was removed through Celite and the filtrate was concentrated under reduced pressure to obtain a title compound (7.56 g).

1. additionAfter the completion of addition
2. temperaturecooling to the reaction mixture
3. customThe precipitate was removed through Celite
4. concentrationthe filtrate was concentrated under reduced pressure

ORDレコード

ord-a8b97054ece845219ed8c188390ad668

出典データセット

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08754100B2