Hydrochloric Acid → Methyl 3-(6-aminopyridazin-4-yl)benzoate

HRID 407075ノート

反応式

HRID 407075 の反応式
Cl.C1(C(=[N:15][C:16]2[N:21]=[N:20][CH:19]=[C:18]([C:22]3[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=3)[C:25]([O:27][CH3:28])=[O:26])[CH:17]=2)C2C=CC=CC=2)C=CC=CC=1.C([O-])([O-])=O.[Na+].[Na+]>C1COCC1>[NH2:15][C:16]1[N:21]=[N:20][CH:19]=[C:18]([C:22]2[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=2)[C:25]([O:27][CH3:28])=[O:26])[CH:17]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 86667185Methyl 3-{6-[(diphenylmethylene)amino]pyridazin-4-yl}benzoate

生成物 1

HCID 67980189Methyl 3-(6-aminopyridazin-4-yl)benzoate収率 218.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.0 M HCl (2.0 mL) was added to a solution of methyl 3-{6-[(diphenylmethylene)amino]pyridazin-4-yl}benzoate (0.16 g, 0.40 mmol) in THF (4.0 mL) and then the reaction was stirred at r.t. for 1.5 h. The mixture was carefully neutralized with Na2CO3 (2.0 eq) and then concentrated under reduced pressure to give the crude product (0.20 g) which was directly used in the next reaction without further purification. LCMS (M+H)+: m/z=230.1

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ca1d88af2bcf43728a4c01ba018c8fa3
出典データセット
uspto-grants-2014_06
特許番号
US08754114B2

反応ノート

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