Dimethyl Sulfoxide → 2-Benzoxazol-2-yl-3,3-bismethylsulfanylacrylonitrile
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][C:11]#[N:12].[C:13](=S)=[S:14].IC.[H-].[Na+].[CH3:20][S:21]([CH3:23])=O>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10](=[C:20]([S:14][CH3:13])[S:21][CH3:23])[C:11]#[N:12]参加物
反応条件
- 温度
- 10 °C
実験手順
To a solution of benzoxazol-2-ylacetonitrile (2.07 g, 13.1 mmol) dissolved in 35 mL of DMSO at room temperature under argon atmosphere was added carbon disulfide (1.10 g, 14.4 mmol) followed by iodomethane (5.20 g, 36.7 mmol). This solution was then cooled to 10° C. and sodium hydride (1.05 g, 60% by wt in oil, 26.3 mmol) was added over a period of several minutes. The solution was allowed to warm to room temperature and stirred overnight. The reaction was then quenched with an ammonium chloride solution and was extracted with 5×50 mL of ethyl acetate. The ethyl acetate was washed with brine solution (3×50 mL) and water (3×30 mL). The organic phase was dried over magnesium sulfate, filtered, and evaporated to yield a red oil. The crude material was purified by flash column chromatography eluting with CH2Cl2:MeOH=98:2 to yield 1.96 g (57%) of the desired product as a yellow oil. MS (m/z, ES+): 236.68 (M+1, 100%). The following examples illustrate the preparation of compounds disclosed in this invention.
後処理
- temperatureto warm to room temperature
- customThe reaction was then quenched with an ammonium chloride solution
- extractionwas extracted with 5×50 mL of ethyl acetate
- washThe ethyl acetate was washed with brine solution (3×50 mL) and water (3×30 mL)
- dry with materialThe organic phase was dried over magnesium sulfate
- filtrationfiltered
- customevaporated
- customto yield a red oil
- customThe crude material was purified by flash column chromatography
- washeluting with CH2Cl2
出典と根拠
- ORDレコード
- ord-c7ef8f1aecf841eb8f4a62dbf8b5fa5f
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08754233B2
反応ノート
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