HCID 59327230、化合物 → 2-Fluoro-3-(tetrahydrofuran-3-YL)pyridine
反応式
[O:1]1[CH:5]=[CH:4][CH:3]([C:6]2[C:7]([F:12])=[N:8][CH:9]=[CH:10][CH:11]=2)[CH2:2]1>C1COCC1.[OH-].[Pd+2].[OH-]>[F:12][C:7]1[C:6]([CH:3]2[CH2:4][CH2:5][O:1][CH2:2]2)=[CH:11][CH:10]=[CH:9][N:8]=1参加物
4
実験手順
A mixture of 3-(2,3-dihydrofuran-3-yl)-2-fluoropyridine (5.26 g, 31.8 mmol) and palladium hydroxide, 20 wt % pd (dry basis) on carbon, wet (2.500 g, 3.56 mmol) in THF (50 mL) was evacuated/purged with hydrogen (3×). The mixture was stirred vigorously under hydrogen (1 atm) at rt overnight. The mixture was filtered through a pad of Celite and the filtrate was concentrated to dryness to give a clear colorless oil. MS (ESI, pos. ion) m/z: 168.1 (M+1).
後処理
- customwas evacuated/purged with hydrogen (3×)
- filtrationThe mixture was filtered through a pad of Celite
- concentrationthe filtrate was concentrated to dryness
- customto give a clear colorless oil
出典と根拠
- ORDレコード
- ord-f988138ca0e54317873e06cbe5ac77e9
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759532B2
反応ノート
読み込み中…