Chlorotrimethylsilane → ((1,1-Dimethyl-2-propynyl)oxy)trimethylsilane

HRID 410438ノート

反応式

HRID 410438 の反応式
[CH3:1][C:2]([OH:6])([C:4]#[CH:5])[CH3:3].CCN(CC)CC.[Si:14](Cl)([CH3:17])([CH3:16])[CH3:15]>CN(C1C=CN=CC=1)C>[CH3:15][Si:14]([CH3:17])([CH3:16])[O:6][C:2]([CH3:3])([C:4]#[CH:5])[CH3:1]

参加物

5

反応物 3

HCID 6397ChlorotrimethylsilaneHCID 82582-Methyl-3-butyn-2-olHCID 8471Triethylamine

生成物 1

HCID 87344((1,1-Dimethyl-2-propynyl)oxy)trimethylsilane収率 57.5%

試薬・触媒・溶媒 1

HCID 142844-(Dimethylamino)pyridine触媒

実験手順

To a solution of 2-methylbut-3-yn-2-ol (140 g, 1.67 mol) was added DMAP (20 g 0.17 mol), Et3N (927 ml, 3.33 mol) and TMS-Cl (289 g, 2.66 mol) at 5 degree under a nitrogen atmosphere. After being stirred one hour, the mixture was washed with water, dried (MgSO4), filtered, concentrated, and distilled to obtain trimethyl[(2-methylbut-3-yn-2-yl)oxy]silane (150 g, 0.96 mol).

後処理

  1. washthe mixture was washed with water
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated
  5. distillationdistilled

出典と根拠

ORDレコード
ord-b49f4e4b7bc34026b242b9757d4ecda6
出典データセット
uspto-grants-2014_06
特許番号
US08759366B2

反応ノート

読み込み中…