1,3-Dibromopropane → HCID 10879224、化合物
反応式
[Br:1][CH2:2][CH2:3][CH2:4]Br.[C:6]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)#[N:7].C([O-])([O-])=O.[K+].[K+]>CC#N>[Br:1][CH2:2][CH2:3][CH2:4][O:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]#[N:7])=[CH:9][CH:10]=1参加物
5
実験手順
1,3-Dibromopropane (1.02 L, 10 mol) was added to a stirred suspension of p-cyanophenol (238 g, 2 mol), K2CO3 (276.4 g, 2 mol) in MeCN (2.7 L). The reaction mixture was refluxed for 4 h, filtered and concentrated. The residue was recrystallised from iso-propyl ether to give the sub-title compound in a 69% yield.
後処理
- temperatureThe reaction mixture was refluxed for 4 h
- filtrationfiltered
- concentrationconcentrated
- customThe residue was recrystallised from iso-propyl ether
出典と根拠
- ORDレコード
- ord-08e0a44d6f884a8aa03702a09a8465e6
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06559143B1
反応ノート
読み込み中…