Diisopropylethylamine → n-[7-((Methanesulfonyl)oxy)naphthyl]-2-[n'-(2-(1-triphenylmethyl-4-imidazolyl)ethyl)amino]acetamide

HRID 412171ノート

反応式

HRID 412171 の反応式
[C:1]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][NH2:15])[N:10]=[CH:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(C(C)C)CC)(C)C.Cl[CH2:38][C:39]([NH:41][C:42]1[C:51]2[C:46](=[CH:47][CH:48]=[C:49]([O:52][S:53]([CH3:56])(=[O:55])=[O:54])[CH:50]=2)[CH:45]=[CH:44][CH:43]=1)=[O:40]>C(#N)C>[CH3:56][S:53]([O:52][C:49]1[CH:50]=[C:51]2[C:46]([CH:45]=[CH:44][CH:43]=[C:42]2[NH:41][C:39](=[O:40])[CH2:38][NH:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][N:8]([C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:12]=2)=[CH:47][CH:48]=1)(=[O:55])=[O:54]

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 6183402-(1-Trityl-1H-imidazol-4-yl)-ethylamineHCID 155493251-(Chloroacetamido)-7-[(methanesulfonyl)oxy]naphthalene

生成物 1

HCID 18536022n-[7-((Methanesulfonyl)oxy)naphthyl]-2-[n'-(2-(1-triphenylmethyl-4-imidazolyl)ethyl)amino]acetamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of the product from Step B (25.6 g, 72.7 mmol) in 200 mL of acetonitrile was added diisopropylethylamine (50 mL, 303 mmol), followed by the product from Step D (19.0 g, 60.5 mmol). The reaction was stirred at room temperature overnight, then concentrated in vacuo. The resulting material was partitioned between EtOAc and water, washed with brine, dried (MgSO4), filtered, and concentrated in vacuo to provide the titled product.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe resulting material was partitioned between EtOAc and water
  3. washwashed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-7f4b809b1d22411c9cb661d6ae3361f0
出典データセット
uspto-grants-2003_05
特許番号
US06562823B1

反応ノート

読み込み中…