Sodium Hydroxide → 1-Methylsulfonyl-2-trifluoromethoxybenzene
反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][C:10]([F:13])([F:12])[F:11].ClC1C=C(C=CC=1)C(OO)=[O:19].[OH-:25].[Na+]>C(Cl)Cl>[CH3:1][S:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][C:10]([F:11])([F:12])[F:13])(=[O:19])=[O:25]参加物
5
実験手順
1-Methylsulfanyl-2-trifluoromethoxybenzene (15.0 g, 72 mmol) was dissolved in DCM (200 mL) and m-chloroperoxybenzoic acid (39.0 g, 216 mmol) was added in small portions during 30 min. The reaction mixture was then allowed to stand overnight. DCM (200 mL) was added followed by slow addition of sodium hydroxide (2 N, 200 mL). The organic phase was separated and washed with sodium hydroxide (2 N, 3×150 mL), dried (magnesium sulphate) and concentrated in vacuo to give 15.8 g of 1-methylsulfonyl-2-trifluoromethoxybenzene
後処理
- customThe organic phase was separated
- washwashed with sodium hydroxide (2 N, 3×150 mL)
- dry with materialdried (magnesium sulphate)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-5d273f08cc454ed69cb6e31b965c5158
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06562807B2
反応ノート
読み込み中…