2,3,5-Trifluoro-6-nitroaniline → 3,4,6-Trifluorobenzene-1,2-diamine

HRID 412727

反応式

HRID 412727 の反応式
[F:1][C:2]1[C:8]([F:9])=[CH:7][C:6]([F:10])=[C:5]([N+:11]([O-])=O)[C:3]=1[NH2:4]>[Pd].C(O)C>[NH2:11][C:5]1[C:6]([F:10])=[CH:7][C:8]([F:9])=[C:2]([F:1])[C:3]=1[NH2:4]

参加物

4

反応物 1

HCID 2230852,3,5-Trifluoro-6-nitroaniline

生成物 1

HCID 5956243,4,6-Trifluorobenzene-1,2-diamine収率 87%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 2,3,5-trifluoro-6-nitroaniline (300 mg, 1.56 mmol) and 10% palladium on carbon in absolute ethanol was hydrogenated overnight at atmospheric pressure, filtered under nitrogen and concentrated to provide 1,2-diamino-3,4,6-trifluorobenzene (219 mg, 87% yield) as a purple crystalline solid; MS M+ 162.7, +41. +82 (+ACN, +2ACN). (calcd for C6H5F3N2: 162.11).

後処理

  1. filtrationfiltered under nitrogen
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-5495ef3acb214113a133c8fbd43a5744
出典データセット
uspto-grants-2003_05
特許番号
US06562854B2

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