Hydrochloric Acid → Benzyl 4-methylidenepyrazolidine-1-carboxylate
反応式
C(OC([N:8]1[CH2:12][C:11](=[CH2:13])[CH2:10][N:9]1[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=O)(C)(C)C.S(Cl)(Cl)=O.Cl>CO>[CH2:17]([O:16][C:14]([N:9]1[CH2:10][C:11](=[CH2:13])[CH2:12][NH:8]1)=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1参加物
5
実験手順
To a solution of crude 4-methylenepyrazolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester, 1, (30 g) in methanol (300 mL) is added thionyl chloride dropwise at 0° C. The reaction is warmed to room temperature and stirred an additional 18 hours. Concentration of the reaction in vacuo affords a yellow oil which crystallizes upon standing to provide 23 g (97% yield) of the desired product as the HCl salt.
後処理
- customConcentration of the reaction in vacuo
- customaffords a yellow oil which
- customcrystallizes
出典と根拠
- ORDレコード
- ord-af422b1a592b4583b747bf5daf50f0f5
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06566357B1
反応ノート
読み込み中…