Ethyl Bromide → 2-Ethoxybenzonitrile
反応式
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH3:17]>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:17]参加物
5
実験手順
25 g (210 mmol) of 2-hydroxybenzonitrile are refluxed with 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide in 500 ml of acetone overnight. The solid is filtered off, the solvent is removed under reduced pressure and the residue is distilled under reduced pressure. This gives 30.0 g (97%) of a colourless liquid.
後処理
- filtrationThe solid is filtered off
- customthe solvent is removed under reduced pressure
- distillationthe residue is distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-07a43eea951d4b759ece091b7f3e811d
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06566360B1
反応ノート
読み込み中…