Mandelic Acid → 10-methoxy-5H-dibenz(b,f)azepine-5-carboxamide

HRID 41346

反応式

HRID 41346 の反応式
[CH3:1][O:2][C:3]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[O-:18][C:19]#[N:20].[Na+].C(O)(=O)C(C1C=CC=CC=1)O.[OH-].[Na+]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([C:19]([NH2:20])=[O:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1

参加物

6

反応物 4

HCID 1292Mandelic AcidHCID 14798Sodium HydroxideHCID 7842410-MethoxyiminostilbeneHCID 517096Sodium Cyanate

生成物 1

HCID 12003110-methoxy-5H-dibenz(b,f)azepine-5-carboxamide収率 83.8%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A suspension of 10 g of 10-methoxyiminostilbene in 200 ml toluene was treated with 20 g of sodium cyanate and 39 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 19 hrs. The resulting suspension was filtered, washed with water and dried to give 10 g of 10-methoxy carbamazepine.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for about 10 hrs
  3. temperaturemaintained for 19 hrs
  4. filtrationThe resulting suspension was filtered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-d481f292f5d5474a8f07a889c5a31c7f
出典データセット
uspto-grants-2013_09
特許番号
US08530647B2

関連ノート

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