Mandelic Acid → Carbamazepine
反応式
[CH:1]1[CH:2]=[CH:3][C:4]2[NH:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[O-:16][C:17]#[N:18].[Na+].C(O)(=O)C(C1C=CC=CC=1)O.[OH-].[Na+]>C1(C)C=CC=CC=1>[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:17]([NH2:18])=[O:16])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1参加物
6
実験手順
A suspension of 10 g of iminostilbene in 100 ml toluene was treated with 20.2 g of sodium cyanate and 27.5 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 8 hrs. The resulting suspension was filtered, washed with water and dried to give 11 g of carbamazepine.
後処理
- temperaturewas heated
- temperatureto reflux for about 10 hrs
- temperaturemaintained for 8 hrs
- filtrationThe resulting suspension was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-9156a4b6f0a14fffb3d533decc5b9669
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530647B2
反応ノート
読み込み中…