Phenacyl bromide → Ethyl 2-acetyl-4-oxo-4-phenylbutanoate

HRID 413883ノート

反応式

HRID 413883 の反応式
[Na].[C:2]([O:8][CH2:9][CH3:10])(=[O:7])[CH2:3][C:4]([CH3:6])=[O:5].Br[CH2:12][C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:14]>C1(C)C=CC=CC=1>[CH2:9]([O:8][C:2](=[O:7])[CH:3]([CH2:12][C:13](=[O:14])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:4](=[O:5])[CH3:6])[CH3:10]

参加物

5

反応物 3

HCID 6259Phenacyl bromideHCID 8868Ethyl AcetoacetateHCID 5360545Sodium2 回

生成物 1

HCID 312893Ethyl 2-acetyl-4-oxo-4-phenylbutanoate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

Sodium metal (60 mmol, 1.4 g) was suspended in 80 mL (milliliter) toluene under nitrogen. Ethyl acetoacetate (88 mmol (millimole), 11.4 g) was added dropwise, and the resulting mixture was stirred until all sodium was consumed. The reaction mixture then was cooled in an ice bath (0-5° C.) and 2-bromoacetophenone (60 mmol, 12 g) in 140 mL toluene was added dropwise. The reaction was stirred overnight with gradual warming to room temperature. Analysis of the reaction mixture by GC and TLC showed that the reaction was complete. The reaction mixture then was washed with 200 mL water, then the organic and aqueous layers were separated. The organic layer was dried over MgSO4 (magnesium sulfate). The toluene was removed from the organic layer under vacuum to provide a yellow oil which was purified by Kugelrohr distillation (b.p. 135-145° C. at 0.35 Torr.).

後処理

  1. customwas consumed
  2. additionwas added dropwise
  3. washThe reaction mixture then was washed with 200 mL water
  4. customthe organic and aqueous layers were separated
  5. dry with materialThe organic layer was dried over MgSO4 (magnesium sulfate)
  6. customThe toluene was removed from the organic layer under vacuum
  7. customto provide a yellow oil which
  8. distillationwas purified by Kugelrohr distillation (b.p. 135-145° C. at 0.35 Torr.)

出典と根拠

ORDレコード
ord-bf9ba01610ac4310ae22c068a2eb2e2d
出典データセット
uspto-grants-2003_05
特許番号
US06569890B2

反応ノート

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