Potassium Carbonate → 6-[(4"-Aminobenzoyl)azo]-8-{[(aminocarbonyl)oxy]methyl}-4,7-dihydroxy-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-azirino[2',3':3,4]pyrrolo[1,2-a)indole
反応式
[CH3:1][C:2]1[C:8](=[O:9])[C:7]2[N:10]3[C@@:14]([O:21][CH3:22])([C@H:15]([CH2:16][O:17][C:18]([NH2:20])=[O:19])[C:6]=2[C:4](=[O:5])[C:3]=1OC)[C@H:13]1[NH:23][C@H:12]1[CH2:11]3.[NH2:26][C:27]1[CH:36]=[CH:35][C:30]([C:31]([NH:33][NH2:34])=[O:32])=[CH:29][CH:28]=1.C(=O)([O-])[O-].[K+].[K+]>>[NH2:26][C:27]1[CH:36]=[CH:35][C:30]([C:31]([N:33]=[N:34][C:3]2[C:2]([CH3:1])=[C:8]([OH:9])[C:7]3[N:10]4[CH2:11][CH:12]5[NH:23][CH:13]5[C:14]4([O:21][CH3:22])[CH:15]([CH2:16][O:17][C:18]([NH2:20])=[O:19])[C:6]=3[C:4]=2[OH:5])=[O:32])=[CH:29][CH:28]=1参加物
4
実験手順
In a similar manner to that described in Example 17, mitomycin A (302 mg), 4-aminobenzoylhydrazine (389 mg) and potassium carbonate (150 mg) are used to obtain the desired product (163 mg) with a yield of 40.5%.