alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol → HCID 14349136、化合物

HRID 414843ノート

反応式

HRID 414843 の反応式
[H-].[Na+].[OH:3][CH:4]([C:10]1[CH:11]=[C:12]([CH:25]=[CH:26][CH:27]=1)[O:13][CH2:14][C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH3:28]I>C(OCC)C>[CH3:28][O:3][CH:4]([C:10]1[CH:11]=[C:12]([CH:25]=[CH:26][CH:27]=1)[O:13][CH2:14][C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

5

反応物 3

HCID 5059alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanolHCID 6328Methyl iodideHCID 24758Sodium hydride

生成物 1

HCID 14349136HCID 14349136、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a suspension of sodium hydride (0.5 g) in ethyl ether at 0° C. is added 2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline (1.8 g) in ether. The mixture is allowed to warm to room temperature. Methyl iodide (0.6 ml) is added and the reaction is stirred at room temperature for three days. The reaction mixture is quenched with saturated aqueous ammonium chloride and extracted with ethyl ether. The organic extract is washed with water, dried (MgSO4) and concentrated to an oil, which is purified by HPLC on silica gel using a 1:9 ratio of ethyl acetate/hexane as an eluent.

後処理

  1. customThe reaction mixture is quenched with saturated aqueous ammonium chloride
  2. extractionextracted with ethyl ether
  3. extractionThe organic extract
  4. washis washed with water
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated to an oil, which
  7. customis purified by HPLC on silica gel using a 1:9 ratio of ethyl acetate/hexane as an eluent

出典と根拠

ORDレコード
ord-69016eb1462448a69dae68a1e73cf313
出典データセット
uspto-grants-1988_12
特許番号
US04794188

反応ノート

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