Dimethylformamide → 3-Nitrophenoxyacetic acid methyl ester
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].CN(C=O)C.C(=O)([O-])[O-].[Na+].[Na+].[CH3:22][O:23][C:24](=[O:27])[CH2:25]Cl>O>[CH3:22][O:23][C:24](=[O:27])[CH2:25][O:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1参加物
6
反応条件
- 温度
- 85 °C
実験手順
300 g of 3-nitrophenol are added to 800 ml of DMF. Then 240 g of sodium carbonate are added portionwise. Subsequently 270 g of chloroacetic acid methylester is added at 22° C. Then the mixture is stirred at 85° C. for six hours. After being cooled down to 25° C. it is given to 3 kg of water and 1 kg of ice. The resulting suspension is filtered off. The filter cake is washed with 300 g of water and dried in vacuum. Yield: 407 g.
後処理
- temperatureAfter being cooled down to 25° C. it
- filtrationThe resulting suspension is filtered off
- washThe filter cake is washed with 300 g of water
- customdried in vacuum
出典と根拠
- ORDレコード
- ord-59738f8d68634a47b39d281b95697ed6
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08088182B2
反応ノート
読み込み中…