4-Toluenesulfonyl chloride → 1-(4-Methylbenzene-1-sulfonyl)-1H-indole-3-carbaldehyde

HRID 41533

反応式

HRID 41533 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[CH:2]1.COCCOC.[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[S:24]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[CH:2]1)([C:21]1[CH:22]=[CH:23][C:18]([CH3:28])=[CH:19][CH:20]=1)(=[O:26])=[O:25]

参加物

4

反応物 3

HCID 73974-Toluenesulfonyl chlorideHCID 80711,2-DimethoxyethaneHCID 10256Indole-3-Carboxaldehyde

生成物 1

HCID 7358171-(4-Methylbenzene-1-sulfonyl)-1H-indole-3-carbaldehyde

実験手順

To a solution of indole-3-carbaldehyde (4.0 g, 27.586 mmol) in 1,2-dimethoxyethane (40 mL) KOH (4.63 g, 82.758 mmol) was added at rt and stirred for 10 min. p-toluene sulfonyl chloride (5.785 g, 30.345 mmol) was added to the solution at rt and stirred for 18 h.

後処理

  1. additionwas added to the solution at rt

出典と根拠

ORDレコード
ord-dc9571d6796a4b6cbea573bdf16c0c9f
出典データセット
uspto-grants-2013_09
特許番号
US08530648B2

関連ノート

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