Ethanol → Trifluoromethoxy phenyl-N-hydroxy-benzamide

HRID 415639

反応式

HRID 415639 の反応式
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7](C#N)=[CH:6][CH:5]=1.Cl.[NH2:15][OH:16].[OH-].[Na+].C[CH2:20][OH:21]>>[F:13][C:2]([F:1])([F:12])[O:3][C:4]1[C:5]([C:4]2[CH:11]=[CH:10][CH:7]=[CH:6][CH:5]=2)=[C:6]([CH:7]=[CH:10][CH:11]=1)[C:20]([NH:15][OH:16])=[O:21]

参加物

5

反応物 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 676214-(Trifluoromethoxy)benzonitrileHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 86643274Trifluoromethoxy phenyl-N-hydroxy-benzamide

実験手順

To a solution of 4-Trifluoromethoxybenzonitrile (1.0 g, 5.0 mmol) in EtOH (20 mL) was added hydroxylamine hydrochloride (0.365 g, 5.0 mmol) and NaOH (0.212 g, 5.0 mmol). The resulting reaction mixture was refluxed for 15 h. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added EtOH and filtered. The filtrate was evaporated in vacuo and used as such for the next step (crude yield 12.0 g, 66%).

後処理

  1. customThe resulting reaction mixture
  2. temperaturewas refluxed for 15 h
  3. customAfter the completion of the reaction (TLC monitoring)
  4. concentrationthe mixture was concentrated
  5. additionadded EtOH
  6. filtrationfiltered
  7. customThe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-c8d553a8b896403caea3eda8a9e78ae2
出典データセット
uspto-grants-2012_01
特許番号
US08088791B2

関連ノート

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