1,1'-Carbonyldiimidazole → 7H-Purin-8-ol

HRID 418389

反応式

HRID 418389 の反応式
[N:1]1[CH:6]=[C:5]([NH2:7])[C:4]([NH2:8])=[N:3][CH:2]=1.[C:9](N1C=CN=C1)(N1C=CN=C1)=[O:10]>O1CCOCC1>[N:1]1[CH:6]=[C:5]2[C:4]([NH:8][C:9](=[O:10])[NH:7]2)=[N:3][CH:2]=1

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 837034,5-Diaminopyrimidine

生成物 1

HCID 2297717H-Purin-8-ol収率 567.7%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
90 °C

実験手順

Pyrimidine-4,5-diamine (1.1 g, 10 mmol) and 1,1′-carbonyl diimidazole 1.78 g, 1.1 mmol) were added to dioxane (15 mL) and the reaction mixture was stirred at 90° C. for 48 hours. The mixture was cooled and the precipitate was recovered by filtration, rinsed with cold dioxane, and dried to give 850 mg (61%) of 7,9-dihydro-purin-8-one.

後処理

  1. temperatureThe mixture was cooled
  2. filtrationthe precipitate was recovered by filtration
  3. washrinsed with cold dioxane
  4. customdried

出典と根拠

ORDレコード
ord-ac24549e369046279c3dddef4a063ea3
出典データセット
uspto-grants-2012_01
特許番号
US08093275B2

関連ノート

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