Hydrochloric Acid → 2-(Methylamino)-3-nitrobenzoic acid
反応式
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[N:13](C)[C:14](=O)C(F)(F)F.[OH-].[Na+].Cl>C1COCC1>[CH3:14][NH:13][C:5]1[C:6]([N+:10]([O-:12])=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:21])=[O:2]参加物
5
反応条件
- 温度
- 50 °C
実験手順
A mixture of 2-[methyl-(2,2,2-trifluoro-acetyl)-amino]-3-nitro-benzoic acid methyl ester (1.7 g, 5.5 mmol) and 5 M aqueous NaOH (5 mL) in THF (10 mL) was stirred at 50° C. for several hours. The mixture was acidified with 4 M HCl and extracted with EtOAc to provide 2-methylamino-3-nitro-benzoic acid. MS m/z: 197.0 (M+H)+.
後処理
- extractionextracted with EtOAc
出典と根拠
- ORDレコード
- ord-0ac1d23363a844a889c22b171fdb40ba
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08093247B2
反応ノート
読み込み中…