Sodium Carbonate → HCID 178513428、化合物

HRID 419692ノート

反応式

HRID 419692 の反応式
Cl.[NH2:2][OH:3].[C:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)#[N:5].C(=O)([O-])[O-].[Na+].[Na+]>O.CO>[OH:3][NH:2][C:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[NH:5]

参加物

6

反応物 3

HCID 10340Sodium CarbonateHCID 73736PiperidinocarbonitrileHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 178513428HCID 178513428、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Amidine (e) is readily produced from nitrites. More specifically, hydroxylamine hydrochloride dissolved in a suitable solvent, such as water, is reacted with cyanopiperidine (g) in the presence of a base such as sodium carbonate in a suitable solvent, such as in methanol and exposed to heat to provide the hydroxycarbamimidoyl-piperidine (h). The hydroxycarbamimidoylpiperidine (h) in a suitable solvent, such as acetic acid, is then hydrogenated via palladium catalyst in the presence of acetic acid anhydride under pressure to provide amidine (e).

後処理

  1. temperatureto heat

出典と根拠

ORDレコード
ord-194efada7bc044ff9ce22b1cd19dc2a6
出典データセット
uspto-grants-2012_01
特許番号
US08093383B2

反応ノート

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