Phosphorus oxybromide → 2-Bromo-5-nitro-3-phenylpyridine

HRID 41981

反応式

HRID 41981 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7](O)=[N:8][CH:9]=1)([O-:3])=[O:2].P(Br)(Br)([Br:19])=O.P(Br)(Br)Br>O>[Br:19][C:7]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][N:8]=1

参加物

5

反応物 3

HCID 24613Phosphorus oxybromideHCID 24614Phosphorus tribromideHCID 1785268355-Nitro-3-phenylpyridin-2-ol

生成物 1

HCID 866572532-Bromo-5-nitro-3-phenylpyridine収率 62%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

A mixture of 5-nitro-3-phenylpyridin-2-ol (4.63 mmol, 1 g), POBr3 (4.74 mmol, 0.45 ml) and PBr3 (4.71 mmol, 1.4 g) was heated at 120° C. for 3.5 hours. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The organic phase was dried and evaporated affording 0.8 g (yield 62%) of the expected product.

後処理

  1. extractionextracted with DCM
  2. customThe organic phase was dried
  3. customevaporated

出典と根拠

ORDレコード
ord-da2a4b647a9443d59f2c8767e3498714
出典データセット
uspto-grants-2013_09
特許番号
US08536165B2

関連ノート

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