Potassium Acetate → 5-Phenylpyridin-3-amine

HRID 41986ノート

反応式

HRID 41986 の反応式
Cl[C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][C:5]([N+:14]([O-])=O)=[CH:4][N:3]=1.CC([O-])=O.[K+]>C(O)C.[Pd]>[C:8]1([C:7]2[CH:6]=[C:5]([NH2:14])[CH:4]=[N:3][CH:2]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

参加物

5

反応物 2

HCID 517044Potassium AcetateHCID 463146982-Chloro-5-nitro-3-phenylpyridine

生成物 1

HCID 27629015-Phenylpyridin-3-amine収率 69%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 2-chloro-5-nitro-3-phenylpyridine (0.43 mmol, 0.1 g), KOAc (0.43 mmol, 0.042 g) and Pd/C 10% (0.03 g) in ethanol (4 ml) was stirred for 24 hours under hydrogen atmosphere. The catalyst was filtered off and the solid thoughtfully washed with warm ethanol. The solid residue was purified by chromatography over SiO2 eluting with dichloromethane/methanol mixtures affording 5-phenylpyridin-3-amine (0.05 g, yield 69%) of the expected product.

後処理

  1. filtrationThe catalyst was filtered off
  2. washthe solid thoughtfully washed with warm ethanol
  3. customThe solid residue was purified by chromatography over SiO2 eluting with dichloromethane/methanol

出典と根拠

ORDレコード
ord-2d7ac8cb0c5048eeba8ab1e599705f42
出典データセット
uspto-grants-2013_09
特許番号
US08536165B2

反応ノート

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