Benzoyl Peroxide → Methyl 2-(bromomethyl)-3-nitrobenzoate

HRID 420613

反応式

HRID 420613 の反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[CH3:13].[Br:15]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C1(=O)NC(=O)CC1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[CH2:13][Br:15]

参加物

6

反応物 4

HCID 7187Benzoyl PeroxideHCID 11439SuccinimideHCID 67184N-bromobutanimideHCID 601165Methyl 2-methyl-3-nitrobenzoate

生成物 1

HCID 1487795Methyl 2-(bromomethyl)-3-nitrobenzoate

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

25.55 g (130.9 mmol) of 2-methyl-3-nitrobenzoic acid methyl ester is added to 300 ml of carbon tetrachloride, and mixed with 25.6 g (141.7 mmol) of N-bromosuccinimide and 62.8 mg of benzoyl peroxide. After seven days of refluxing, the succinimide is suctioned off after cooling, and then the filtrate is spun in until a dry state is reached. The desired compound that is incorporated in crude form into the next stage remains.

後処理

  1. temperatureAfter seven days of refluxing
  2. temperatureafter cooling

出典と根拠

ORDレコード
ord-bac3f96a75ac43479751c769eee1363d
出典データセット
uspto-grants-2012_01
特許番号
US08097627B2

関連ノート

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