Lithium Hydroxide → Lithium 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate
反応式
O1CCCC1.[O:6]=[C:7]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=1)[CH2:8][C:9]([O:11]CC)=[O:10].[OH-].[Li+:26]>O>[O:6]=[C:7]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:22])([F:23])[F:24])[CH:16]=1)[CH2:8][C:9]([O-:11])=[O:10].[Li+:26]参加物
5
実験手順
To a tetrahydrofuran (350 ml) solution of ethyl 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate (5 g, 18.17 mmol) (Example 1A) is added lithium hydroxide (435 mg, 18.17 mmol) in water (150 ml). The solution is stirred at room temperature for 4 hours, and then concentrated to afford a white solid. The crude product is used without further purification.
後処理
- concentrationconcentrated
- customto afford a white solid
- customThe crude product is used without further purification
出典と根拠
- ORDレコード
- ord-7caa9bac3510457781c6753dbcb19315
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08097629B2
反応ノート
読み込み中…