Methanol → Methyl 2-chloro-4-methylbenzoate

HRID 420753

反応式

HRID 420753 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].O=S(Cl)Cl.[CH3:16]O>>[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:16])=[O:5]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 27357552-Chloro-4-methylbenzoic acid

生成物 1

HCID 22019481Methyl 2-chloro-4-methylbenzoate

実験手順

2-chloro-4-methylbenzoic acid (500 mg, 2.93 mmol) was dissolved in Methanol (7 mL) and SOCl2 (0.215 mL, 2.93 mmol) was slowly added to the mixture and the reaction was left at room temperature overnight. Next morning HPLC showed completion. Volatiles were removed under vacuum to afford 526 mg of the title compound as brown oil.

後処理

  1. customVolatiles were removed under vacuum

出典と根拠

ORDレコード
ord-816d5ce1e99a4848bd036311ac824933
出典データセット
uspto-grants-2012_01
特許番号
US08097628B2

関連ノート

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