Hydrochloric Acid → N-(3,4-Dimethoxyphenyl)-N-(phenylsulfonyl)glycine

反応式

[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([N:13]([CH2:23][C:24]([O:26]CC)=[O:25])[S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:8]=[CH:9][C:10]=1[O:11][CH3:12].Cl>O1CCCC1>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([N:13]([CH2:23][C:24]([OH:26])=[O:25])[S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]

参加物

実験手順

A 20 ml portion of 1 M sodium hydroxide aqueous solution was added to a tetrahydrofuran solution (20 ml) of 2.48 g of ethyl [(3,4-dimethoxyphenyl)(phenylsulfonyl)amino]acetate and stirred at room temperature for 2 hours. This was acidified by adding 1 M hydrochloric acid and then layer separation operation was carried out by adding chloroform thereto, and the organic layer was washed with saturated brine, dried with anhydrous sodium sulfate and then concentrated under a reduced pressure to obtain 2.28 g of [(3,4-dimethoxyphenyl)(phenylsulfonyl)amino]acetic acid as a pale yellow foamy substance.